Cardiff Rugby will host Sale Sharks on Saturday, April 1 (8pm), in the European Challenge Cup Round of 16.
The Blue and Blacks secured a home fixture after winning three from four pool stage encounters in the competition.
They now take on the in-form English outfit with a quarter-final place, against either Benetton Rugby or Connacht, up for grabs.
Tickets will be released exclusively to Cardiff Rugby season members at 9am on Friday, January 27, and will then go on public sale at 9am on Tuesday, January 31.
The Early Bird window for tickets, offering the best possible price, will be open until March 17, when the general match prices come into effect.