Danny Wilson’s side sit on the top of Pool 2 after two rounds of games, where they secured a bonus point victory against Lyon at Cardiff Arms Park and a historic 15-17 win at Stade Ernest Wallon against Top 14 giants, Toulouse.
Toulouse’s victory over Lyon on Thursday takes them within one point of Wales' Capital Region, but the Blues have a game in-hand over the French outfit.
Seb Davies returns from international duty as one of eight changes for the trip to the AJ Bell Stadium.
Matthew Rees returns to captain the side at hooker, while Taufa'ao Filise’s suspension delays his 250th appearance for the region, with Anton Peikrishvili taking his place at tighthead. James Down is also reintroduced to the pack.
Gareth Anscombe moves to the number 10 jersey, while Lloyd Williams, Rey Lee-Lo, Matthew Morgan and Aled Summerhill make a return to the backline.
Tomos Williams is named on the bench and is in line to make his 50th appearance for the region.
Meanwhile, Sale Sharks have made 13 changes from last week’s win over Worcester Warriors, with Springboks centre, Rohan Janse van Rensburg making his debut for the Salford-based club.
England wing, Denny Solomona, is named in the starting XV, while Blaine Scully’s USA team-mate, AJ McGinty, lines up at outside half.
Former Cardiff Blues academy prop, Will Griff John, is named in the front row and experienced Australia international, James O’Connor, is named amongst the replacements.
What They Said
Danny Wilson insists his side will draw confidence from the victories over Lyon and Toulouse, and the Cardiff Blues head coach has highlighted the threat posed by the in-form Sharks side, who go into the clash on the back of back-to-back victories in the Premiership.
"The first reminder to the boys is that we're top of the group with nine points," said Wilson.
"We had a good start with a bonus point win and an away win at Toulouse, which was a massive lift for all of us at the time, which led to confidence in the PRO14 and a few good wins.
"Obviously the weekend was tough following the red card, but we need to bounce straight back to draw on the confidence we had from earlier matches in this competition and take that to Sale.
"Sale are a side that are going pretty well in the Aviva Premiership at the moment, they've had some good results and we know, given the firepower and squad depth they've got, that it's going to be a big ask but one we're certainly motivated and confident for."
Sale Sharks: Mike Haley; Denny Solomona, Mark Jennings, Rohan Janse Van Rensburg, Josh Charnley; AJ McGinty, Will Cliff; Ross Harrison, Marc Jones, Will Griff John, George Nott, Andrei Ostrikov, Cameron Neild, Ben Curry, Jono Ross (C)
Replacements: Rob Webber, James Flynn, Alexandru Tarus, Matt Postlethwaite, David Seymour, Faf De Klerk, Sam James, James O'Connor.
Cardiff Blues: Matthew Morgan; Owen Lane, Garyn Smith, Rey Lee-Lo, Aled Summerhill; Gareth Anscombe, Lloyd Williams; Brad Thyer, Matthew Rees (C), Anton Peikrishvili, George Earle, James Down, Seb Davies, Josh Turnbull, Nick Williams
Replacements: Kirby Myhill, Corey Domachowski, Keiron Assiratti, Damian Welch, Sion Bennett, Tomos Williams, Jarrod Evans, Blaine Scully