Cardiff Blues are forced into a number of late changes ahead of the European Rugby Challenge Cup encounter with Harlequins at Twickenham Stoop (kick-off 3.15pm).
Wing Tom James and back row Josh Navidi are both ruled out of the fixture in London through illness.
Ellis Jenkins comes into the side to make his 50th appearance for the region while USA international Blaine Scully also gets a start on the wing.
There is also a change on the bench where an ankle injury rules out Jarrad Hoeata. His place among the replacements is taken by Lou Reed.
Cardiff Blues: 15 Dan Fish, 14 Alex Cuthbert, 13 Cory Allen, 12 Rey Lee-Lo, 11 Blane Scully, 10 Rhys Patchell, 9 Lloyd Williams (c); 1 Sam Hobbs, 2 Kristian Dacey, 3 Taufa’ao Filise, 4 Macauley Cook, 5 James Down, 6 Josh Turnbull, 7 Ellis Jenkins, 8 Manoa Vosawai
Replacements: 16 Ethan Lewis, 17 Thomas Davies, 18 Dillon Lewis, 19 Lou Reed, 20 Cam Dolan, 21 Tavis Knoyle, 22 Gareth Anscombe, 23 Gavin Evans