Gareth Anscombe will retain the Wales number 10 jersey as Warren Gatland's side prepare to take on Australia in the 2018 Under Armour Series.
The Cardiff Blues outside half starred in last week's 21-10 victory over Scotland, setting up tries for George North and Jonathan Davies.
Ellis Jenkins makes a return from injury, and is included on the bench alongside regional team-mates, Tomos Williams and Dillon Lewis.
Prop, Lewis, was another who impressed against Gregor Townsend's side last week, but is replaced by Tomas Francis at tighthead prop.
Gatland has made a total of three changes for the Wallabies Test - with Josh Adams and Adam Beard replacing Luke Morgan and Cory Hill respectively.
British and Irish Lions duo, Dan Biggar and Liam Williams, who represent Northampton Saints and Saracens, are both included in the matchday 23 for the first time during this campaign.
Wales team to play Australia: Leigh Halfpenny (Scarlets); George North (Ospreys), Jonathan Davies (Scarlets), Hadleigh Parkes (Scarlets), Josh Adams (Worcester Warriors); Gareth Anscombe (Cardiff Blues), Gareth Davies (Scarlets); Nicky Smith (Ospreys), Ken Owens (Scarlets), Tomas Francis (Exeter Chiefs), Adam Beard (Ospreys), Alun Wyn Jones (Ospreys, capt.), Dan Lydiate (Ospreys), Justin Tipuric (Ospreys), Ross Moriarty (Dragons)
Replacements: Elliot Dee (Dragons), Rob Evans (Scarlets), Dillon Lewis (Cardiff Blues), Cory Hill (Dragons), Ellis Jenkins (Cardiff Blues), Tomos Williams (Cardiff Blues), Dan Biggar (Northampton Saints), Liam Williams (Saracens)