Blues currently top Pool 2 with an undefeated record after victories over Newcastle Falcons, Scarlets and Wasps and victory on home soil this weekend will guarantee them a semi-final spot.
However, Leicester Tigers also top their pool and arrive in Cardiff also determined to cement a place in the final four.
Cardiff Blues make just one change in the pack as Lou Reed is recalled in the second row to partner Miles Normandale, who this week agreed a new two-year contract at the region.
A new-look half back pairing will see Gareth Davies and Tavis Knoyle combine.
Geraint Walsh is named at full back, with Argentine Joaquin Tuculet moving into the centre to join forces with Adam Thomas. The final change sees a call-up for winger Owen Jenkins.
There are several changes to the replacements bench with Ethan Lewis, Taufa’ao Filise, Lloyd Williams, Craig Lodge and Jack Phillips ready to make an impression.
Skills Coach Lee Jarvis said: “Ultimately you play the game to challenge for trophies; it’s what you want as players and coaches. We have the opportunity to do just that by booking a place in the semi-finals of the LV=Cup.
“Leicester will also want a home semi-final so we’ve got to be at our very best and go all out for the win. It’s all set up to be a great game and hopefully we will have a big crowd in to support the team.”
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Cardiff Blues: 15 Geraint Walsh, 14 Owen Jenkins, 13 Joaquin Tuculet, 12 Adam Thomas, 11 Lucas Amorosino, 10 Gareth Davies, 9 Tavis Knoyle; 1 Thomas Davies, 2 Rhys Williams, 3 Craig Mitchell, 4 Miles Normandale, 5 Lou Reed, 6 Macauley Cook, 7 Ellis Jenkins (c), 8 James Sheekey
Replacements: 16 Ethan Lewis, 17 Brad Thyer, 18 Taufa’ao Filise, 19 Ben Roach, 20 Craig Lodge, 21 Lloyd Williams, 22 Rhys Patchell, 23 Jack Phillips